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Our Approach to Improve Hair Loss by Increasing Hair Growth Factor IGF-1

IGF-1 (Insulin-like growth factor 1) is well known as a hair growing substance. However, it has not long been established how to increase IGF-I production without adverse effects. Dr. Okajima found that stimulation of sensory neuron safely increases IGF-I production in the body.

Based on this discovery, JHGC offers innovative methods by which IGF-I production is increased in the hair follicle. These methods will contribute to the restoration of normal hair growth and improvement of hair loss.

"IGF-1 (insulin-like growth factor)" is a very important growth factor produced in cells throughout the body and it plays critical roles not only in promoting the physical growth but in boosting the immune system and healing power of the body. The growth factor is also produced in the hair follicle and promotes hair growth by proliferating keratinocytes, thereby improving alopecia. IGF-1 is decreased due to any reasons such as stress and aging, which induces hair loss. Therefore, promotion of IGF-I production by the safe method is critical for maintenance of normal hair growth and also for restoration of hair growing power in patients with alopecia.

Effect of IGF-1.

Inhibit DHT to reverse hair loss, and actively promote hair growth by increasing IGF-1, which accelerates hair growth by increasing IGF-1, which accelerates hair growth/hair restoration.
  • Mechanism of IGF-1 production in the hair follicle
    Sensory neurons that transmit the pain and heat sensation to the brain perceive the stimulatory information in the gastrointestinal tract and the skin, thereby releasing CGRP (calcitonin gene-related peptide) in the hair follicle. Dermal papilla cells increase IGF-I production by receiving CGRP, and IGF-I thus formed activates keratinocytes to increase its proliferation. Consequently, hair growth is promoted by sensory neuron stimulation in the gastrointestinal tract and scalp.
  • DHT decreases IGF-I production
    A powerful hair losing hormone called "DHT = dihydrotestosterone" is formed from testosterone by the action of an enzyme called "5α-reductase" in hair follicles. DHT inhibits IGF-I production by inhibiting sensory neuron stimulation, thereby inducing hair loss.
  • Synergistic effect of treatments that increase IGF-1 production and the other treatments that inhibit DHT formation
    Finasteride that inhibits DHT formation has recently been used to treat AGA, and, thus, it has become a hot topic. Since DHT inhibits IGF-I production, inhibition of DHT formation by finasteride or the other scalp care and treatments that increase IGF-I production may synergistically increase IGF-I production, thereby promoting hair growth; the former means release of brake of hair growth and the latter stepping on accelerator of hair growth. JHGC provides these synergistic treatments based on the above-mentioned theory established by extensive research.
  • The effects of IGF-1 on the hair growth
    • Increase blood flow of hair root
    • Promotion of hair growth and hair restoration
    • Prevention of hair loss
    • Melanin hyperpigmentation of hair
    • Enhance hair dryness and luster

Hair Growth Acceleration

Increasing IGF-1 production to “reverses hair loss”
It is also beneficial for "improving sagging wrinkle skin" and “preventing lifestyle related diseases” in addition to promoting hair growth.

Only JHGC provides hair care treatments based on the IGF-1 hair growth theory in the world.

Dr. Kenji Okajima

Dr. Kenji Okajima Nagoya K Clinics Director. In the course of conducting research focusing on hematology primarily, he found a new way to increase the insulin-like growth factor which has the hair growth effect, and completed "IGF-1 hair growth theory" with isoflavone and capsaicin. This discovery is applied to the development of treatment methods that has demonstrated various effects of anti-aging effect such as rejuvenation of skin besides hair restoration. He has many publications on hair growth.


1978 Graduated from Kumamoto University
1982 Completed Graduate school studies in Kumamoto University Graduate School of Medicine (Department of Biochemistry)
1988 Assistant in Kumamoto University, Medical School (clinical examination medicine course)
1991 Study abroad in Austria Vienna Medical University School of Medicine National Institute for Physiological Sciences as a Researcher dispatched by Japan Society for for the Promotion of Science in the specific country
1992 Kumamoto University lecturer
1996 Kumamoto University Associate Professor
2005 He was appointed as a Professor in Nagoya City University Graduate School of Medicine
2012 Opened Nagoya K Clinics